Bench research in animal models by combining cutting-edge imaging/sensing technologies and molecular/genetic manipulations enables us to delve into the cellular and molecular mechanisms of human diseases.

Representative publications:

  1. S. Da Mesquita, A. Louveau, A. Vaccari, I. Smirnov, RC. Cornelison, KM. Kingsmore, C. Contarino, S. Onengut-Gumuscu, E. Farber, D. Raper, KE. Viar, RD. Powell, W. Baker, N. Dabhi, R. Cao, S. Hu, S. Rich, JM. Munson, CC. Overall, ST. Acton, J. Kipnis. “Functional aspects of meningeal lymphatics in aging and Alzheimer’s disease,” Nature 560, 185-191 (2018).
  2. R. Cao, J. Li, Y. Kharel, C. Zhang, K. Lynch, Z. Zuo, S. Hu. “Photoacoustic microscopy of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke,” Theranostics, 8(22), 6111-6120 (2018).
    doi: 10.7150/thno.29435
  3. R. Cao, C. Zhang, V. Mitkin, M. Lankford, J. Li, Z. Zuo, C. Meyer, C. Goyne, S. Ahlers, J. Stone, S. Hu. “Comprehensive characterization of cerebrovascular dysfunction in blast traumatic brain injury using photoacoustic microscopy,” Journal of Neurotrauma, 36(10):1526-1534 (2019).
  4. N. Sun, S. Zheng, D. Rosin, N. Poudel, J. Yao, H. Perry, R. Cao, M. Okusa, S. Hu, “Development of a photoacoustic microscopy technique to assess peritubular capillary function and oxygen metabolism in the mouse kidney,” Kidney International 100.3 (2021): 613-620. (Featured on cover)
  5. T. Keller, J. Butcher, G. Broseghini-Filho, C. Marziano, L. DeLalio, S. Rogers, B. Ning, J. Martin, S. Chechova, M. Cabot, X. Shu, A. Best, M. Good, A. Padilha, M. Purdy, M. Yeager, S. Peirce, S. Hu, A. Doctor, E. Barrett, T. Le, L. Columbus, and B. Isakson, “Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbaX),” Hypertension, 68(6), 1494-1503 (2016).

Clinical translation of the bench-validated technologies improves disease theranostics and reveals new observations that stimulate further bench research.

Representative publications:

  1. Y. Zhou, X. Yi, W. Xing, S. Hu, K. Maslov, and L. V. Wang, “Microcirculatory changes identified by photoacoustic microscopy in patients with complex regional pain syndrome type I after stellate ganglion blocks,” J. Biomed. Opt. 19(8), 086017 (2014).