75. Zhuoying Wang, Yifeng Zhou, and Song Hu, “Sparse Coding-enabled Low-fluence Multi-parametric Photoacoustic Microscopy,” IEEE Transactions on Medical Imaging (accepted).

74. SG. Sathyanarayana†, Z. Wang†, N. Sun, B. Ning, S. Hu*, JA. Hossack*, “Recovering blood flow information from undersampled data in photoacoustic microscopy using sparse modeling,” IEEE Transactions on Medical Imaging (accepted; *: corresponding author; †: equal contribution).

73. V. Sciortino, A. Tran, N. Sun, R. Cao, T. Sun, Y. Sun, P. Yan, F. Zhong, Y. Zhou, C. Kuan, JM. Lee, S. Hu, “Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy,” Journal of Cerebral Blood Flow & Metabolism, 0(0) 1-13, 2021.

72. N. Sun, S. Zheng, D. Rosin, N. Poudel, J. Yao, H. Perry, R. Cao, M. Okusa, S. Hu, “Photoacoustic Microscopy of Peritubular Capillary Function and Oxygen Metabolism in Mouse Kidney,” Kidney International (accepted).

71. Y. Zhou, F. Zhong, S. Hu, “Temporal and spectral unmixing of photoacoustic signals by deep learning,” Optics Letters, 46, 2690-2693 (2021).

70. Y. Zhou, F. Zhong, JM. Lee, S. Hu, “Simultaneous imaging of amyloid deposition and cerebrovascular function using dual-contrast photoacoustic microscopy,” Optics Letters. 46, 2561-2564 (2021).

69. R. Cao, A. Tran, J. Li, Z. Xu, N. Sun, Z. Zuo, S. Hu, “Hemodynamic and Oxygen-metabolic Responses of the Awake Mouse Brain to Hypercapnia Revealed by Multi-parametric Photoacoustic Microscopy,” Journal of Cerebral Blood Flow and Metabolism, April 2021.


68. N. Poudel, S. Zheng, CM. Schinderle, N. Sun, S. Hu, MD. Okusa, “Peritubular Capillary Oxygen Consumption in Sepsis-Induced AKI: Multi-Parametric Photoacoustic Microscopy,” Nephron, 144(12):621-625 (2020).

67. PS. Cottler, N. Sun, JM. Thuman, K. Bielak, L. Salopek, A. Piñeros-Fernandez, S. Hu, CA. Campbell, “The biointegration of a porcine acellular dermal matrix in a novel radiated breast reconstruction model”, Annals of Plastic Surgery, 84:S417-S423 (2020).

66. F. Zhong, Y. Bao, R. Chen, Q. Zhou, S. Hu, “High-speed wide-field multi-parametric photoacoustic microscopy,” Optics Letters, 45(10), 2756-2759 (2020).

65. N. Sun, B. Ning, A. Bruce, R. Cao, S. Seaman, T. Wang, R. Fritsche-Danielson, L. Carlsson, S. Peirce, S. Hu, “In vivo imaging of hemodynamic redistribution and arteriogenesis across microvascular network,” Microcirculation, e12598 (2020).


64. Z. Xu, N. Sun, R. Cao, Z. Li, Q. Liu, S. Hu. “Cortex-wide multi-parametric photoacoustic microscopy based on real-time contour scanning,” Neurophotonics, 6(3), 035012 (2019).
63. AL. Klibanov, S. Hu. “Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D,” Cancer Research, 79(18):4577-4579 (2019).
62. Z. Xu, Y. Wang, N. Sun, Z. Li, S. Hu, Q. Liu. “Parallel computing for quantitative blood flow imaging in photoacoustic microscopy,” Sensors, 19(18), 4000 (2019).
61. R. Cao, C. Zhang, V. Mitkin, M. Lankford, J. Li, Z. Zuo, C. Meyer, C. Goyne, S. Ahlers, J. Stone, S. Hu. “Comprehensive characterization of cerebrovascular dysfunction in blast traumatic brain injury using photoacoustic microscopy,” Journal of Neurotrauma, 36(10):1526-1534 (2019).
60. PS. Cottler, JB. Olenczak, B. Ning, SA. Seaman, JM. Thuman, N. Sun, A. Piñeros-Fernandez, S. Hu, BR. DeGeorge Jr, CA. Campbell. “Fenestration improves acellular dermal matrix biointegration: an investigation of revascularization with photoacoustic microscopy”, Plastic and Reconstructive Surgery, 143(4):971-981 (2019).
59. R. Cao, J. Li, C. Zhang, Z. Zuo, S. Hu. “Photoacoustic microscopy of obesity-induced cerebrovascular alterations,” NeuroImage, 188:369-379 (2019).
58. T. Wang, N. Sun, R. Chen, Q. Zhou, S. Hu. “Isotropic-resolution photoacoustic microscopy with multi-angle illumination,” Optics Letters, 44(1), 1-4 (2019).


57. R. Cao, J. Li, Y. Kharel, C. Zhang, K. Lynch, Z. Zuo, S. Hu. “Photoacoustic microscopy of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke,” Theranostics, 8(22), 6111-6120 (2018).
56. N. Sun, B. Ning, AC. Bruce, SA. Seaman, M. Rikard, CA. DeRosa, CL. Fraser, M. Wågberg, R. Fritsche-Danielson, J. Wikström, KR. Chien, A. Lundahl, M. Hölttä, K. Hansson, L. Carlsson, SM. Peirce, S. Hu. “Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing,” Scientific Reports, 8, 17509 (2018).
55. A. Norambuena, H. Wallrabe, R. Cao, DB. Wang, A. Silva, Z. Svindrych, S. Hu, RE. Tanzi, DY. Kim, GS. Bloom, “A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers,” EMBO Journal, 37(22), e100241 (2018).
54. A. Louveau, J. Herz, M. Alme, M. Dong, K. Viar, G. Herod, J. Knopp, J. Setliff, A. Lupi, S. Gabriel Ferreira Da Mesquita, E. Frost , R. Cao, S. Hu, J. Lukens, I. Smirnov, C. Overall, A. Salvador, G. Oliver, J. Kipnis. “CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature,” Nature Neuroscience, 21, 1380-1391 (2018).
53. S. Da Mesquita, A. Louveau, A. Vaccari, I. Smirnov, RC. Cornelison, KM. Kingsmore, C. Contarino, S. Onengut-Gumuscu, E. Farber, D. Raper, KE. Viar, RD. Powell, W. Baker, N. Dabhi, R. Cao, S. Hu, S. Rich, JM. Munson, CC. Overall, ST. Acton, J. Kipnis. “Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease,” Nature 560, 185-191 (2018).
52. SG. Sathyanarayana, B. Ning, R. Cao, S. Hu, JA. Hossack. “Dictionary learning-based reverberation removal enables depth-resolved photoacoustic microscopy of cortical microvasculature in the mouse brain,” Scientific Reports, 8, 985 (2018).
51. H. Wallrabea, Z. Svindrych, SR. Alama, KH. Siller, T. Wang, D. Kashatus, S. Hu, A. Periasamy. “Segmented cell analyses to measure redox states of autofluorescent NAD(P)H, FAD & Trp in cancer cells by FLIM,” Scientific Reports, 8, 79 (2018).


50. M. Gutknecht, M. Seaman, B. Ning, D. Cornejo, E. Mugler, P. Antkowiak, C. Moskaluk, S. Hu, FH. Epstein, KA. Kelly. “Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity.” Nature Communications, 8(1), 552 (2017).
49. M. Kelly-Goss, B. Ning, A. Bruce, D. Tavakol, D. Yi, S. Hu, PA. Yates, SM. Peirce. “Dynamic, heterogeneous endothelial Tie2 expression and capillary blood flow during microvascular remodeling.” Scientific Reports, 7:9049 (2017).
48. R. Cao, J. Li, B. Ning, N. Sun, T. Wang, Z. Zuo, and S. Hu, “Functional and Oxygen-metabolic Photoacoustic Microscopy of the Awake Mouse Brain”, NeuroImage, 150: 77-87 (2017).
47. B. DeGeorge Jr., B. Ning, L. Salopek, A. Pineros-Fernandez, G. Rodeheaver, S. Peirce-Cottler, S. Hu, P. Cottler, C. Campbell, “Advanced imaging techniques for the investigation of acellular dermal matrix biointegration”, Plastic and Reconstructive Surgery, 139(2): 395-405 (2017).


46. T. Wang, N. Sun, R. Cao, B. Ning, R. Chen, Q. Zhou, and S. Hu, “Multi-parametric photoacoustic microscopy of the mouse brain with 300-kHz A-line rate”, Neurophotonics, 3(4), 045006 (2016).
45. R. Cao and S. Hu, “Molecular Photoacoustic Imaging of Energy Metabolism,” Molecular Imaging Gateway, 10(3) (2016).
44. T. Keller, J. Butcher, G. Broseghini-Filho, C. Marziano, L. DeLalio, S. Rogers, B. Ning, J. Martin, S. Chechova, M. Cabot, X. Shu, A. Best, M. Good, A. Padilha, M. Purdy, M. Yeager, S. Peirce, S. Hu, A. Doctor, E. Barrett, T. Le, L. Columbus and B. Isakson, “Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbaX),” Hypertension, 68(6), 1494-1503 (2016).
43. Y. Cho, G. Zheng, G. Augustine, D. Hochbaum, A. Cohen, T. Knöpfel, F. Pisanello, F. Pavone, I. Vellekoop, M. Booth, S. Hu, J. Zhu, Z. Chen, and Y. Hoshi “Roadmap on neurophotonics,” Journal of Optics, 18(9), 093007 (2016).
42. J. Song, F. Wang, X. Yang, B. Ning, Harp,G. M. Culp, S. Hu, P. Huang, L. Nie, J. Chen, and X. Chen, “Gold nanoparticle coated carbon nanotube ring with enhanced raman scattering and photothermal conversion property for theranostic applications,” Journal of the American Chemical Society, 138(22), 7005-7015 (2016).
41. S. Hu, “Emerging concepts in functional and molecular photoacoustic imaging,” Current Opinion in Chemical Biology, 33, 25-31(2016).
40. C. Yeh, J. Liang, Y. Zhou, S. Hu, R. E. Sohn, J. M. Arbeit, and L. V. Wang, “Photoacoustic microscopy of arteriovenous shunts and blood diffusion in early-stage tumors,” Journal of Biomedical Optics, 21(2), 020501-020501 (2016).
39. S. Hu, “Listening to the brain with photoacoustics,” IEEE Journal of Selected Topics in Quantum Electronics, 22(3), 6800610 (2016).


38. B. Ning, N. Sun, R. Cao, R. Chen, K. K. Shung, J. A. Hossack, J.-M. Lee, Q. Zhou, and S. Hu, “Ultrasound-aided multi-parametric photoacoustic microscopy of the mouse Brain,” Scientific Reports, 5, 18775 (2015).
37. K. Song, P. Huang, C. Yi, B. Ning, S. Hu, L. Nie, X. Chen, and Z. Nie, “Photoacoustic and Colorimetric Visualization of Latent Fingerprints,”ACS nano, 9(12), DOI: 10.1021/acsnano.5b05618 (2015).
36. T. Wang, R. Cao, B. Ning, A. J. Dixon, J. A. Hossack, A. L. Klibanov, Q. Zhou, A. Wang and S. Hu, “All-optical photoacoustic microscopy based on plasmonic detection of broadband ultrasound,” Applied Physics Letters. 107, 153702 (2015).
35. A. J. Dixon, S. Hu, A. L. Klibanov, and J. A. Hossack, “Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles,” Small, 11(25), 3066–3077 (2015).
34. R. Cao, J. P. Kilroy, B. Ning, T. Wang, J. A. Hossack, and S. Hu, “Multispectral photoacoustic microscopy based on an optical-acoustic objective,” Photoacoustics, 3(2), 55-59 (2015).
33. B. Ning, M. J. Kennedy, A. J. Dixon, N. Sun, R. Cao, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, J. A. Hossack, and S. Hu, “Simultaneous photoacoustic microscopy of microvascular anatomy, oxygen saturation, and blood flow,” Optics Letters, 40(6), 910-913 (2015).


32. L. Li, C. Yeh, S. Hu, L. Wang, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, K. I. Maslov, and L. V. Wang, “Fully motorized optical-resolution photoacoustic microscopy,” Opt. Lett. 39, 2117-2120 (2014).
31.Y. Zhou, X. Yi, W. Xing, S. Hu, K. Maslov, and L. V. Wang, “Microcirculatory changes identified by photoacoustic microscopy in patients with complex regional pain syndrome type I after stellate ganglion blocks,” J. Biomed. Opt. 19(8), 086017 (2014).
30. C. Yeh, B. Soetikno, S. Hu, K. I. Maslov, and L. V. Wang, “Microvascular quantification based on contour-scanning photoacoustic microscopy,” J. Biomed. Opt. 19(9), 096011 (2014).
29. C. Yeh, B. Soetikno, S. Hu, K. I. Maslov, and L. V. Wang, “Three-dimensional arbitrary trajectory scanning photoacoustic microscopy,” J. Biophoton., 201400055 (2014).


28. S. Hu, and L. V. Wang. “Optical-resolution photoacoustic microscopy: auscultation of biological systems at the cellular level,” Biophysical journal 105, no. 4 (2013): 841-847.
27.L. V. Wang and S. Hu, “Photoacoustic tomography is ready to revolutionize,” BioOptics World 6, 32–37 (2013). (Featured on the cover)
27. S. Hu, and L. V. Wang. “Optical-resolution photoacoustic microscopy: auscultation of biological systems at the cellular level,” Biophysical journal 105, no. 4 (2013): 841-847.
26. C. Yeh;, S. Hu;, K. Maslov, and L. V. Wang, “Photoacoustic microscopy of blood pulse wave”, Journal of Biomedical Optics 17(7), 070504 (2012).
25. L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458-1462 (2012).
24. P. K. Avti;, S. Hu;, C. P. Favazza;, A. G. Mikos, J. A. Jansen, K. R. Shroyer, L. V. Wang, and B. Sitharaman, “Detection, mapping, and quantification of single walled carbon nanotubes in histological specimens with photoacoustic microscopy,” PLoS One 7(4), e35064 (2012).
23. C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” Journal of Biomedical Optics 17(2), 020501 (2012).
22. X. Cai;, B. S. Paratala;, S. Hu;, B. Sitharaman, and L. V. Wang, “Multiscale Photoacoustic Microscopy of Single-Walled Carbon Nanotube-Incorporated Tissue Engineering Scaffolds,” Tissue Engineering Part C: Methods 18(4), doi:10.1089/ten.tec.2011.0519 (2012).
21. S. Oladipupo;, S. Hu;, J. Kovalski, J. Yao, A. C. Santeford, R. Sohn, R. V. Shohet, K. Maslov, L. V. Wang, and J. M. Arbeit, “VEGF is essential for hypoxia-inducible factor mediated neovascularization but dispensable for endothelial sprouting,” Proceedings of the National Academy of Sciences 108(32), 13264-13269 (2011).
20. V. Tsytsarev;, S. Hu;, J. Yao, K. Maslov, D. L. Barbour, and L. V. Wang, “Photoacoustic microscopy of microvascular responses to cortical electrical stimulation,” Journal of Biomedical Optics 16(7), 076002 (2011). (Selected for inclusion in Faculty of 1000)
19. H.-W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J.-X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Physical Review Letters 106(23), 238106 (2011). (Highlighted by Science)
18. S. Hu, K. Maslov, and L. V. Wang, “Three-dimensional optical-resolution photoacoustic microscopy,” Journal of Visualized Experiments, doi: 10.3791/2729 (2011).
17. S. Oladipupo;, S. Hu;, A. C. Santeford, J. Yao, J. Kovalski, R. V. Shohet, K. Maslov, L. V. Wang, and J. M. Arbeit, “Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence,” Blood 117(15), 4142-4153 (2011).
16. S. Hu;, K. Maslov;, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Optics Letters 36(7), 1134–1136 (2011). (Featured article)
15. Y. Wang, S. Hu, K. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure,” Optics Letters 36(7), 1029–1031 (2011).
14. Y. Wang, K. Maslov, Y. Zhang, S. Hu, L. Yang, Y. Xia, J. Liu, L. V. Wang, “Fiber-laser-based photoacoustic microscopy and melanoma cell detection,” Journal of Biomedical Optics 16(1), 011014 (2011).
13. Y. Wang, K. Maslov, C. Kim, S. Hu, and L. V. Wang, “Integrated photoacoustic and fluorescence confocal microscopy,” IEEE Transactions on Biomedical Engineering 57(10), 2576–2578 (2010).
12. S. Hu and L. V. Wang, “Neurovascular photoacoustic tomography,” Frontiers in Neuroenergetics 2(10), doi:10.3389/fnene.2010.00010 (2010).
11. Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in three-dimensional photoacoustic microscopy of biological tissue,” Optics Letters 35(12), 2067–2069 (2010).
10. S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” Journal of Biomedical Optics 15(1), 011101 (2010). (4th most cited article in Journal of Biomedical Optics since 2009)
9. S. Hu, B. Rao, K. Maslov, and L. V. Wang, “Label-free photoacoustic ophthalmic angiography,” Optics Letters 35(1), 1–3 (2010). (Featured by Virtual Journal of Biomedical Optics)
8. S. Hu;, P. Yan;, K. Maslov, J.-M. Lee, and L. V. Wang, “Intravital imaging of amyloid plaques in a transgenic mouse model using optical-resolution photoacoustic microscopy,” Optics Letters 34(24), 3899–3901 (2009).
7. J. Yao, K. Maslov, S. Hu, and L. V. Wang, “Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo,” Journal of Biomedical Optics 14(5), 054049 (2009).
6. S. Hu, K. Maslov, V. Tsytsarev, and L. V. Wang, “Functional transcranial brain imaging by optical-resolution photoacoustic microscopy,” Journal of Biomedical Optics 14(4), 040503 (2009). (6th most cited article in Journal of Biomedical Optics since 2009)
5. S. Hu, K. Maslov, and L. V. Wang, “In vivo functional chronic imaging of a small animal model using optical-resolution photoacoustic microscopy,” Medical Physics 36(6), 2320-2323 (2009).
4. S. Hu, K. Maslov, and L. V. Wang, “Noninvasive label-free imaging of microhemodynamics by optical-resolution photoacoustic microscopy,” Optics Express 17(9), 7688-7693 (2009).
3. K. Maslov;, H. F. Zhang;, S. Hu;, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Optics Letters 33(9), 929–931 (2008). (5th most cited article in Optics Letters since 2007)
2. Y. Wang, S. Hu, L. Yan, J.-Y. Yang, and A. E. Willner, “Chromatic dispersion and polarization mode dispersion monitoring for multi-level intensity and phase modulation systems,” Optics Express 15(21), 14038-14043 (2007).
1. S. Hu, H. Zhang, and Y. Guo, “Stiffness analysis in the numerical solution of Raman amplifier propagation equation,” Optics Express 12(8), 1656-1664 (2004).