Development of next-generation photoacoustic imaging techniques with unconventional spatiotemporal resolution, tissue penetration, and functional/molecular contrast.

Representative publications:

  1. Y. Zhou, F. Zhong, JM. Lee, S. Hu, “Simultaneous imaging of amyloid deposition and cerebrovascular function using dual-contrast photoacoustic microscopy,” Optics Letters. 46, 2561-2564 (2021). (Featured by Spotlight on Optics
  2. V. Sciortino, A. Tran, N. Sun, R. Cao, T. Sun, Y. Sun, P. Yan, F. Zhong, Y. Zhou, C. Kuan, JM. Lee, S. Hu, “Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy,” Journal of Cerebral Blood Flow & Metabolism, 41, no. 12 (2021): 3187-3199.
  3. F. Zhong, Y. Bao, R. Chen, Q. Zhou, S. Hu, “High-speed wide-field multi-parametric photoacoustic microscopy,” Optics Letters, 45(10), 2756-2759 (2020).
  4. R. Cao, J. Li, B. Ning, N. Sun, T. Wang, Z. Zuo, and S. Hu, “Functional and Oxygen-metabolic Photoacoustic Microscopy of the Awake Mouse Brain”, NeuroImage, 150: 77-87 (2017).
  5. B. Ning, N. Sun, R. Cao, R. Chen, K. K. Shung, J. A. Hossack, J.-M. Lee, Q. Zhou, and S. Hu, “Ultrasound-aided multi-parametric photoacoustic microscopy of the Mouse Brain,” Scientific Reports, 5, 18775 (2015).
  6. B. Ning, M. J. Kennedy, A. J. Dixon, N. Sun, R. Cao, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, J. A. Hossack, and S. Hu, “Simultaneous photoacoustic microscopy of microvascular anatomy, oxygen saturation, and blood flow,” Optics Letters, 40(6), 910-913 (2015).

Integration of cutting-edge optical, photoacoustic, and/or ultrasonic imaging techniques with complementary contrasts for comprehensive assessments of cellular and molecular mechanisms in vivo.


Development of first-of-a-kind optical fiber-based miniature devices for minimally-invasive functional and molecular imaging and sensing of deep tissue in vivo beyond the reach of conventional technologies.


Fabrication of imaging and sensing micro/nano devices with ultra-high spatial resolution and unconventional properties using novel ultrafast laser-based 3D printing and writing.